Current smoking status is associated to a non-ACR 50 response in early rheumatoid arthritis. A cohort study
Identifieur interne : 001568 ( Main/Exploration ); précédent : 001567; suivant : 001569Current smoking status is associated to a non-ACR 50 response in early rheumatoid arthritis. A cohort study
Auteurs : Jorge Rojas-Serrano [Mexique] ; Leticia Lino Pérez [Mexique] ; Conrado García García [Mexique] ; Francisco Moctezuma [Mexique] ; Everardo Álvarez-Hernández [Mexique] ; Janitzia Vázquez-Mellado [Mexique] ; José Luis Montiel [Mexique] ; Rubén Burgos-Vargas [Mexique]Source :
- Clinical Rheumatology [ 0770-3198 ] ; 2011-12-01.
English descriptors
- KwdEn :
Abstract
Abstract: The purpose of this study is to determine factors associated with a non-ACR 50 response at 6 months of follow-up, in a cohort of patients with early rheumatoid arthritis (RA). Early RA patients (symptom duration <1 year), treated with the same combination treatment (methotrexate and sulfasalazine), were included. Demographic characteristics of the patients including current smoker status (defined as a patient that smokes at least one cigarette per day), years of formal education, a 28-joint count for swelling and tenderness were registered. A basal HAQ questionnaire, visual scales for global assessment, and pain were answered by all patients, and a CDAI basal score was calculated. The ACR 50 response was determined at 6 months follow-up. Multivariable logistic regression analysis was used to calculate adjusted ORs. Two hundred twenty-five patients were evaluated, but only 144 had a complete follow-up, 43% of the latter did not reach an ACR 50 response. The only factor associated with this outcome was current smoking (OR 3.58, P < 0.008, 95% CI 1.23–11.22). Low level of formal education (≤6 years) had a tendency towards a statistical difference (P < 0.08). After controlling with low level of formal education, sex, age in years, and CDAI baseline value with multivariable logistic regression analysis, current smoking status had an adjusted OR of 3.91 (P < 0.009, 95% CI 1.41–10.81). Smoking is associated with a non-ACR 50 response in early rheumatoid arthritis in patients treated with a combination therapy with methotrexate and sulfasalazine.
Url:
DOI: 10.1007/s10067-011-1775-5
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001F05
- to stream Istex, to step Curation: 001F05
- to stream Istex, to step Checkpoint: 000544
- to stream Main, to step Merge: 001570
- to stream Main, to step Curation: 001568
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Current smoking status is associated to a non-ACR 50 response in early rheumatoid arthritis. A cohort study</title><author><name sortKey="Rojas Serrano, Jorge" sort="Rojas Serrano, Jorge" uniqKey="Rojas Serrano J" first="Jorge" last="Rojas-Serrano">Jorge Rojas-Serrano</name></author><author><name sortKey="Perez, Leticia Lino" sort="Perez, Leticia Lino" uniqKey="Perez L" first="Leticia Lino" last="Pérez">Leticia Lino Pérez</name></author><author><name sortKey="Garcia, Conrado Garcia" sort="Garcia, Conrado Garcia" uniqKey="Garcia C" first="Conrado García" last="García">Conrado García García</name></author><author><name sortKey="Moctezuma, Francisco" sort="Moctezuma, Francisco" uniqKey="Moctezuma F" first="Francisco" last="Moctezuma">Francisco Moctezuma</name></author><author><name sortKey="Alvarez Hernandez, Everardo" sort="Alvarez Hernandez, Everardo" uniqKey="Alvarez Hernandez E" first="Everardo" last="Álvarez-Hernández">Everardo Álvarez-Hernández</name></author><author><name sortKey="Vazquez Mellado, Janitzia" sort="Vazquez Mellado, Janitzia" uniqKey="Vazquez Mellado J" first="Janitzia" last="Vázquez-Mellado">Janitzia Vázquez-Mellado</name></author><author><name sortKey="Montiel, Jose Luis" sort="Montiel, Jose Luis" uniqKey="Montiel J" first="José Luis" last="Montiel">José Luis Montiel</name></author><author><name sortKey="Burgos Vargas, Ruben" sort="Burgos Vargas, Ruben" uniqKey="Burgos Vargas R" first="Rubén" last="Burgos-Vargas">Rubén Burgos-Vargas</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:32146B4C9F763382B0127713652689FEEA340BA6</idno><date when="2011" year="2011">2011</date><idno type="doi">10.1007/s10067-011-1775-5</idno><idno type="url">https://api.istex.fr/ark:/67375/VQC-MVSBSK0P-P/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">001F05</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001F05</idno><idno type="wicri:Area/Istex/Curation">001F05</idno><idno type="wicri:Area/Istex/Checkpoint">000544</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000544</idno><idno type="wicri:doubleKey">0770-3198:2011:Rojas Serrano J:current:smoking:status</idno><idno type="wicri:Area/Main/Merge">001570</idno><idno type="wicri:Area/Main/Curation">001568</idno><idno type="wicri:Area/Main/Exploration">001568</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Current smoking status is associated to a non-ACR 50 response in early rheumatoid arthritis. A cohort study</title><author><name sortKey="Rojas Serrano, Jorge" sort="Rojas Serrano, Jorge" uniqKey="Rojas Serrano J" first="Jorge" last="Rojas-Serrano">Jorge Rojas-Serrano</name><affiliation wicri:level="1"><country xml:lang="fr">Mexique</country><wicri:regionArea>Instituto Nacional de Enfermedades Respiratorias, Ismael Cosío Villegas, Universidad Nacional Autónoma de México, Faculty of Medicine, Mexico City</wicri:regionArea><wicri:noRegion>Mexico City</wicri:noRegion></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Mexique</country></affiliation></author><author><name sortKey="Perez, Leticia Lino" sort="Perez, Leticia Lino" uniqKey="Perez L" first="Leticia Lino" last="Pérez">Leticia Lino Pérez</name><affiliation wicri:level="1"><country xml:lang="fr">Mexique</country><wicri:regionArea>Department of Rheumatology, Hospital General de México, Mexico City</wicri:regionArea><wicri:noRegion>Mexico City</wicri:noRegion></affiliation></author><author><name sortKey="Garcia, Conrado Garcia" sort="Garcia, Conrado Garcia" uniqKey="Garcia C" first="Conrado García" last="García">Conrado García García</name><affiliation wicri:level="1"><country xml:lang="fr">Mexique</country><wicri:regionArea>Department of Rheumatology, Hospital General de México, Mexico City</wicri:regionArea><wicri:noRegion>Mexico City</wicri:noRegion></affiliation></author><author><name sortKey="Moctezuma, Francisco" sort="Moctezuma, Francisco" uniqKey="Moctezuma F" first="Francisco" last="Moctezuma">Francisco Moctezuma</name><affiliation wicri:level="1"><country xml:lang="fr">Mexique</country><wicri:regionArea>Department of Rheumatology, Hospital General de México, Mexico City</wicri:regionArea><wicri:noRegion>Mexico City</wicri:noRegion></affiliation></author><author><name sortKey="Alvarez Hernandez, Everardo" sort="Alvarez Hernandez, Everardo" uniqKey="Alvarez Hernandez E" first="Everardo" last="Álvarez-Hernández">Everardo Álvarez-Hernández</name><affiliation wicri:level="1"><country xml:lang="fr">Mexique</country><wicri:regionArea>Department of Rheumatology, Hospital General de México, Mexico City</wicri:regionArea><wicri:noRegion>Mexico City</wicri:noRegion></affiliation></author><author><name sortKey="Vazquez Mellado, Janitzia" sort="Vazquez Mellado, Janitzia" uniqKey="Vazquez Mellado J" first="Janitzia" last="Vázquez-Mellado">Janitzia Vázquez-Mellado</name><affiliation wicri:level="1"><country xml:lang="fr">Mexique</country><wicri:regionArea>Department of Rheumatology, Hospital General de México, Mexico City</wicri:regionArea><wicri:noRegion>Mexico City</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Mexique</country><wicri:regionArea>Universidad Nacional Autónoma de México, Faculty of Medicine, Mexico City</wicri:regionArea><wicri:noRegion>Mexico City</wicri:noRegion></affiliation></author><author><name sortKey="Montiel, Jose Luis" sort="Montiel, Jose Luis" uniqKey="Montiel J" first="José Luis" last="Montiel">José Luis Montiel</name><affiliation wicri:level="1"><country xml:lang="fr">Mexique</country><wicri:regionArea>Universidad Autónoma del Estado de Morelos, Facultad de Farmacia, Mexico City</wicri:regionArea><wicri:noRegion>Mexico City</wicri:noRegion></affiliation></author><author><name sortKey="Burgos Vargas, Ruben" sort="Burgos Vargas, Ruben" uniqKey="Burgos Vargas R" first="Rubén" last="Burgos-Vargas">Rubén Burgos-Vargas</name><affiliation wicri:level="1"><country xml:lang="fr">Mexique</country><wicri:regionArea>Department of Rheumatology, Hospital General de México, Mexico City</wicri:regionArea><wicri:noRegion>Mexico City</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Mexique</country><wicri:regionArea>Universidad Nacional Autónoma de México, Faculty of Medicine, Mexico City</wicri:regionArea><wicri:noRegion>Mexico City</wicri:noRegion></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Mexique</country></affiliation></author></analytic><monogr></monogr><series><title level="j">Clinical Rheumatology</title><title level="j" type="sub">Journal of the International League of Associations for Rheumatology</title><title level="j" type="abbrev">Clin Rheumatol</title><idno type="ISSN">0770-3198</idno><idno type="eISSN">1434-9949</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>London</pubPlace><date type="published" when="2011-12-01">2011-12-01</date><biblScope unit="volume">30</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="page" from="1589">1589</biblScope><biblScope unit="page" to="1593">1593</biblScope></imprint><idno type="ISSN">0770-3198</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0770-3198</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Early rheumatoid arthritis</term><term>Methotrexate</term><term>Prognostic factors</term><term>Rheumatoid arthritis</term><term>Sulfasalazine</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: The purpose of this study is to determine factors associated with a non-ACR 50 response at 6 months of follow-up, in a cohort of patients with early rheumatoid arthritis (RA). Early RA patients (symptom duration <1 year), treated with the same combination treatment (methotrexate and sulfasalazine), were included. Demographic characteristics of the patients including current smoker status (defined as a patient that smokes at least one cigarette per day), years of formal education, a 28-joint count for swelling and tenderness were registered. A basal HAQ questionnaire, visual scales for global assessment, and pain were answered by all patients, and a CDAI basal score was calculated. The ACR 50 response was determined at 6 months follow-up. Multivariable logistic regression analysis was used to calculate adjusted ORs. Two hundred twenty-five patients were evaluated, but only 144 had a complete follow-up, 43% of the latter did not reach an ACR 50 response. The only factor associated with this outcome was current smoking (OR 3.58, P < 0.008, 95% CI 1.23–11.22). Low level of formal education (≤6 years) had a tendency towards a statistical difference (P < 0.08). After controlling with low level of formal education, sex, age in years, and CDAI baseline value with multivariable logistic regression analysis, current smoking status had an adjusted OR of 3.91 (P < 0.009, 95% CI 1.41–10.81). Smoking is associated with a non-ACR 50 response in early rheumatoid arthritis in patients treated with a combination therapy with methotrexate and sulfasalazine.</div></front></TEI><affiliations><list><country><li>Mexique</li></country></list><tree><country name="Mexique"><noRegion><name sortKey="Rojas Serrano, Jorge" sort="Rojas Serrano, Jorge" uniqKey="Rojas Serrano J" first="Jorge" last="Rojas-Serrano">Jorge Rojas-Serrano</name></noRegion><name sortKey="Alvarez Hernandez, Everardo" sort="Alvarez Hernandez, Everardo" uniqKey="Alvarez Hernandez E" first="Everardo" last="Álvarez-Hernández">Everardo Álvarez-Hernández</name><name sortKey="Burgos Vargas, Ruben" sort="Burgos Vargas, Ruben" uniqKey="Burgos Vargas R" first="Rubén" last="Burgos-Vargas">Rubén Burgos-Vargas</name><name sortKey="Burgos Vargas, Ruben" sort="Burgos Vargas, Ruben" uniqKey="Burgos Vargas R" first="Rubén" last="Burgos-Vargas">Rubén Burgos-Vargas</name><name sortKey="Burgos Vargas, Ruben" sort="Burgos Vargas, Ruben" uniqKey="Burgos Vargas R" first="Rubén" last="Burgos-Vargas">Rubén Burgos-Vargas</name><name sortKey="Garcia, Conrado Garcia" sort="Garcia, Conrado Garcia" uniqKey="Garcia C" first="Conrado García" last="García">Conrado García García</name><name sortKey="Moctezuma, Francisco" sort="Moctezuma, Francisco" uniqKey="Moctezuma F" first="Francisco" last="Moctezuma">Francisco Moctezuma</name><name sortKey="Montiel, Jose Luis" sort="Montiel, Jose Luis" uniqKey="Montiel J" first="José Luis" last="Montiel">José Luis Montiel</name><name sortKey="Perez, Leticia Lino" sort="Perez, Leticia Lino" uniqKey="Perez L" first="Leticia Lino" last="Pérez">Leticia Lino Pérez</name><name sortKey="Rojas Serrano, Jorge" sort="Rojas Serrano, Jorge" uniqKey="Rojas Serrano J" first="Jorge" last="Rojas-Serrano">Jorge Rojas-Serrano</name><name sortKey="Vazquez Mellado, Janitzia" sort="Vazquez Mellado, Janitzia" uniqKey="Vazquez Mellado J" first="Janitzia" last="Vázquez-Mellado">Janitzia Vázquez-Mellado</name><name sortKey="Vazquez Mellado, Janitzia" sort="Vazquez Mellado, Janitzia" uniqKey="Vazquez Mellado J" first="Janitzia" last="Vázquez-Mellado">Janitzia Vázquez-Mellado</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001568 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001568 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:32146B4C9F763382B0127713652689FEEA340BA6
|texte= Current smoking status is associated to a non-ACR 50 response in early rheumatoid arthritis. A cohort study
}}
| This area was generated with Dilib version V0.6.33. |  |